Table 4.
Summary of membrane bound proteins—other ligand gated membrane protein results.
| References | Model | Cell line/tissue | Species (receptor) | Receptor subtype | Xenon dose | Outcome reported | Direction of effect |
|---|---|---|---|---|---|---|---|
| GABA | |||||||
| Hapfelmeier et al. (2000) | Cultured cells | HEK 293 | Rat | α1β2/α1β2γ2λ | 100% | Ionic current | ↑↔* |
| Yamakura and Harris (2000) | Cultured cells | Xenopus oocytes | Human | α1β2g2s | 46% | Ionic current | ↑ |
| de Sousa et al. (2000) | Cultured cells | Hippocampal neurones | Rats | 80% | Charge transfer | ↔ | |
| Gruss et al. (2004) | Cultured cells | HEK293 | Human | α1β2g2s | 80% | Ionic current | ↔ |
| Haseneder et al. (2008) | Tissue slice | Amygdala | Mouse | 65% | Ionic current | ↔ | |
| Haseneder et al. (2009b) | Tissue slice | Prefrontal cortex | Mouse | 65% | Ionic current | ↔ | |
| Haseneder et al. (2009b) | Tissue slice | Dorsal spinal cord | Mouse | 65% | Ionic current | ↔ | |
| Georgiev et al. (2010) | Tissue slice | Dorsal spinal cord | Rat | 50% | Ionic current | ↔ | |
| Georgiev et al. (2010) | Tissue slice | Dorsal spinal cord | Rat | 50% | Presynaptic transmission | ↔ | |
| Yamamoto et al. (2012) | Tissue slice | Ventral spinal cord | Rat | 50% | Ionic current | ↔ | |
| Yamamoto et al. (2012) | Tissue slice | Ventral spinal cord | Rat | 50% | Presynaptic transmission | ↔ | |
| Yamamoto et al. (2012) | Tissue slice | Ventral spinal cord | Rat | 50% | Postsynaptic transmission | ↔ | |
| Nonaka et al. (2019) | Single bouton | Hippocampal CA3 neurone | Rats | 70% | Ionic current | ↔ | |
| Nonaka et al. (2019) | Single bouton | Hippocampal CA3 neurone | Rats | 70% | Presynaptic transmission | ↓ | |
| Nonaka et al. (2019) | Single bouton | Hippocampal CA3 neurone | Rats | 70% | Postsynaptic transmission | ↔ | |
| Nonaka et al. (2019) | Single bouton | Hippocampal CA3 neurone | Rats | 30% | Presynaptic transmission | ↓ | |
| Nonaka et al. (2019) | Single bouton | Hippocampal CA3 neurone | Rats | 30% | Postsynaptic transmission | ↔ | |
| Kubota et al. (2020) | Single bouton | SDCN | Rat | 70% | Ionic current | ↔ | |
| Kubota et al. (2020) | Single bouton | SDCN | Rat | 70% | Presynaptic transmission | ↓ | |
| Kubota et al. (2020) | Single bouton | SDCN | Rat | 70% | Postsynaptic transmission | ↔ | |
| Glycine | |||||||
| Daniels and Roberts (1998) | Cultured cells | Xenopus oocytes | Human | α1 | 40% | Ionic current | ↑ |
| Daniels and Roberts (1998) | Cultured cells | Xenopus oocytes | Human | α1 | 70% | Ionic current | ↑ |
| Yamakura and Harris (2000) | Cultured cells | Xenopus oocytes | Human | α1 | 46% | Ionic current | ↑ |
| Georgiev et al. (2010) | Tissue slice | Dorsal spinal cord | Rat | 50% | Ionic current | ↔ | |
| Yamamoto et al. (2012) | Tissue slice | Ventral spinal cord | Rat | 50% | Ionic current | ↔ | |
| Other | |||||||
| Yamakura and Harris (2000) | Cultured cells | Xenopus oocytes | Rat | nACh α4β2/α4β4 | 46% | Ionic current | ↓ |
| Suzuki et al. (2003) | Cultured cells | xenopus oocytes | Human | nACh α7 receptor | 35% | Ionic current | ↓ |
| Suzuki et al. (2002) | Cultured cells | Xenopus oocytes | Human | 5HT3α | 35-100% | Ionic current | ↓ |
Direction of effect: ↑–Increased, ↓–Reduced, ↔–No change.
Color of arrow represents statistics presented by authors: Green—p-value in comparison to control given, Amber—no p-value but standard error of mean presented for xenon and control groups, Red—p-value/SEM not given for xenon and control groups.
Presynaptic transmission include measures of miniature, spontaneous and evoked potentials that indicate presynaptic mechanisms. Postsynaptic transmission include miniature, spontaneous and evoked potentials that indicate postsynaptic mechanisms. Details given within text.
SDCN, Sacral dorsal commissural nucleus.
Dependent on experimental conditions, see text for details.