Table 5.
Summary of membrane bound proteins—non-ligand gated proteins.
| References | Model | Cell line/tissue | Species (receptor) | Receptor subtype | Xenon dose | Outcome reported | Direction of effect |
|---|---|---|---|---|---|---|---|
| Calcium channels | |||||||
| Horn et al. (1995) | Cultured cells | Cerebral synaptosomes | Rat | PMCA | 124% | Pumping actvity | ↓ |
| Singh et al. (1995) | Cultured cells | C6 glioma synaptosomes | Rat | PMCA | 50–150% | Pumping actvity | ↓ |
| Franks et al. (1995) | Cultured cells | Cerebral synaptosomes | Rat | PMCA | 124% | Pumping actvity | ↓ |
| Franks J. J. et al. (1998) | Cultured cells | Cerebral cortex | Mouse | PMCA | 20/40% | Intracellular calcium | ↔ |
| Franks J. J. et al. (1998) | Cultured cells | Cerebral cortex | Mouse | PMCA | 60/80% | Intracellular calcium | ↑ |
| White et al. (2005) | Cultured cells | HEK293 | Rat | N-type | 80% | Ionic current | ↔ |
| Kratzer et al. (2012) | Tissue slice | CA1 hippocampal neurones | Mouse | L-type | 65% | Ionic current | ↔ |
| Kubota et al. (2020) | Single bouton | SDCN | Rat | Voltage gated | 70% | Ionic current | ↔ |
| Potassium channels | |||||||
| Gruss et al. (2004) | Cultured cells | HEK293 | Human | TASK-3 | 80% | Ionic current | ↔ |
| Gruss et al. (2004) | Cultured cells | HEK293 | Human | TREK-1 | 80% | Ionic current | ↑ |
| Bantel et al. (2009) | Cultured cells | HEK293 | Mouse/Rat | KATP (Kir6.2/SUR1) | 50% | Ionic current | ↔ |
| Bantel et al. (2009) | Cultured cells | HEK293 | Mouse/Rat | KATP (Kir6.2/SUR1) | 80% | Ionic current | ↑ |
| Bantel et al. (2010) | Cultured cells | HEK293 | Mouse/Rat | KATP (Kir6.2/SUR1) | 80% | Ionic current | ↑ |
| Bantel et al. (2010) | Cultured cells | HEK293 | Mouse/Rat | Kir1.1 | 80% | Ionic current | ↔ |
| Harris et al. (2013) | Cultured cells | HEK293 | Human | TREK-1 | 80% | Ionic current | ↑ |
| Mattusch et al. (2015) | Cultured cells | HEK293 | Mouse | HCN2 | 65% | Ionic current | ↓ |
| Mattusch et al. (2015) | Tissue slice | Cortex | Mouse | HCN2 | 65% | Ionic current | ↓ |
| Mattusch et al. (2015) | Tissue slice | Cortex | Mouse | HCN2 | 65% | Signal propagation | ↓ |
| Monoamine transport | |||||||
| David et al. (2006) | Tissue slice | Nucleus accumbens | Rat | DAT | 50–75% | DA release | ↓ |
| David et al. (2008) | Tissue slice | Corpus striatum | Rat | DAT | 25–75% | DA release | ↓ |
| Neukirchen et al. (2012) | Cultured cells | HEK293 | Human | NET | 65% | NA uptake | ↔ |
| Neukirchen et al. (2012) | Cultured cells | SH-SY5Y | Human | NMDA/NET | 50%/65% | NA uptake | ↓ |
| Others | |||||||
| White et al. (2011) | Cultured cells | Primary sensory neurones | Rat | TRPV1 | 75% | Cobalt uptake | ↓ |
| White et al. (2011) | Cultured cells | HEK293 | Human | TRPV1 | 75% | Cobalt uptake | ↓ |
| Lehmke et al. (2018) | Cultured cells | Xenopus oocytes | Rat | ASIC | 71% | Ionic current | ↓ |
| Kubota et al. (2020) | Single bouton | SDCN | Rat | Voltage gated Na+ | 70% | Ionic current | ↔ |
Direction of effect: ↑–Increased, ↓–Reduced, ↔–No change.
Color of arrow represents statistics presented by authors: Green—p-value in comparison to control given, Amber—no p-value but standard error of mean presented for xenon and control groups, Red—p-value/SEM not given for xenon and control groups.
SDCN, Sacral dorsal commissural nucleus.