Table 6.
Protein quantification summary.
| References | Protein | Tissue | Species | Injury model | Route xenon | Xenon dose | Xenon duration | Direction of effect |
|---|---|---|---|---|---|---|---|---|
| Cattano et al. (2008) | ADNP | Brain | Rat | No | Inhaled | 75% | 2 h | ↑ |
| Peng et al. (2013) | Akt | Brain | Rat | Yes | Injected | 7 mg.kg−1 | N/A | ↑ |
| Dandekar et al. (2018) | Akt | Brain | Rat | No | Injected | 6/9 mg.kg−1 | N/A | ↔ |
| Fan et al. (2021) | Akt | Spinal cord | Rat | Yes | Inhaled | 50% | 2 h | ↔ |
| Limatola et al. (2010) | Akt-p | Brain | Mouse | Yes | Inhaled | 70% | 2 h | ↑ |
| Peng et al. (2013) | Akt-p | Brain | Rat | Yes | Injected | 7 mg.kg−1 | N/A | ↔ |
| Liu et al. (2016) | Akt-p | Spinal cord | Rat | Yes | Inhaled | 50% | 1 h | ↑ |
| Dandekar et al. (2018) | Akt-p | Brain | Rat | No | Injected | 6/9 mg.kg−1 | N/A | ↔ |
| Fan et al. (2021) | Akt-p | Spinal cord | Rat | Yes | Inhaled | 50% | 2 h | ↑ |
| Zhuang et al. (2012) | Bax | Brain | Rat | Yes | Inhaled | 70% | 1.5 h | ↓ |
| Yang et al. (2014) | Bax | Spinal cord | Rat | Yes | Inhaled | 50% | 1 h | ↓ |
| Jin et al. (2021) | Bax | Brain | Mouse | Yes | Injected | 200 μL | N/A | ↓ |
| Ma et al. (2006) | Bcl-2 | Brain | Rat | No | Inhaled | 70% | 2 h | ↑ |
| Shu et al. (2010) | Bcl-2 | Brain | Rat | Yes | Inhaled | 70% | 2 h | ↑ |
| Zhuang et al. (2012) | Bcl-2 | Brain | Rat | Yes | Inhaled | 70% | 1.5 h | ↑ |
| Yang et al. (2014) | Bcl-2 | Spinal cord | Rat | Yes | Inhaled | 50% | 1 h | ↑ |
| Zhao et al. (2018) | Bcl-2 | Brain | Rat | Yes | Inhaled | 50% | 3 h | ↑ |
| Jin et al. (2021) | Bcl-2 | Brain | Mouse | Yes | Injected | 200 μL | N/A | ↑ |
| Ma et al. (2006) | BDNF | Brain | Rat | No | Inhaled | 70% | 2 h | ↑ |
| Peng et al. (2013) | BDNF | Brain | Rat | Yes | Injected | 7 mg.kg−1 | N/A | ↑ |
| Dandekar et al. (2018) | BDNF | Brain | Rat | No | Injected | 6/9 mg.kg−1 | N/A | ↔ |
| Ma et al. (2007) | Caspase 3 | Brain | Rat | No | Inhaled | 75% | 6 h | ↔ |
| Shu et al. (2010) | Caspase 3 | Brain | Rat | Yes | Inhaled | 70% | 2 h | ↓ |
| Yang et al. (2014) | Caspase 3 | Spinal cord | Rat | Yes | Inhaled | 50% | 1 h | ↓ |
| Jin et al. (2021) | Caspase 3 | Brain | Mouse | Yes | Injected | 200 μL | N/A | ↓ |
| Ma et al. (2007) | Caspase 8 | Brain | Rat | No | Inhaled | 75% | 6 h | ↔ |
| Ma et al. (2007) | Caspase 9 | Brain | Rat | No | Inhaled | 75% | 6 h | ↔ |
| Fan et al. (2021) | CREB | Spinal cord | Rat | Yes | Inhaled | 50% | 2 h | ↔ |
| Ma et al. (2006) | CREB-p | Brain | Rat | No | Inhaled | 70% | 2 h | ↑ |
| Luo et al. (2008) | CREB-p | Brain | Rat | Yes | Inhaled | 75% | 2 h | ↑ |
| Fan et al. (2021) | CREB-p | Spinal cord | Rat | Yes | Inhaled | 50% | 2 h | ↑ |
| Ma et al. (2007) | Cyt-c | Brain | Rat | No | Inhaled | 75% | 6 h | ↔ |
| Shu et al. (2010) | Cyt-c | Brain | Rat | Yes | Inhaled | 70% | 2 h | ↔ |
| Yang et al. (2014) | Cyt-c | Spinal cord | Rat | Yes | Inhaled | 50% | 1 h | ↓ |
| Kuzovlev et al. (2021) | GSK3β | Brain | Rat | No | Inhaled | 55% | 30 min | ↔ |
| Kuzovlev et al. (2021) | GSK3β-p | Brain | Rat | No | Inhaled | 55% | 30 min | ↑ |
| Limatola et al. (2010) | HIF1a | Brain | Mouse | Yes | Inhaled | 70% | 2 h | ↑ |
| Vizcaychipi et al. (2011) | Hsp72 | Brain | Mouse | Yes | Inhaled | 70% | 20 min | ↔ |
| Dandekar et al. (2018) | MAPK | Brain | Rat | No | Injected | 6/9 mg.kg−1 | N/A | ↔ |
| Dandekar et al. (2018) | MAPK-p | Brain | Rat | No | Injected | 6/9 mg.kg−1 | N/A | ↔ |
| Liu et al. (2016) | MAPK-p | Spinal cord | Rat | Yes | Inhaled | 50% | 1 h | ↑ |
| Peng et al. (2013) | MAPK-p | Brain | Rat | Yes | Injected | 7 mg.kg−1 | N/A | ↑ |
| Shu et al. (2010) | MAPK-p | Brain | Rat | Yes | Inhaled | 70% | 2 h | ↔ |
| Peng et al. (2013) | MAPK-p42 | Brain | Rat | Yes | Injected | 7 mg.kg−1 | N/A | ↑ |
| Peng et al. (2013) | MAPK-p44 | Brain | Rat | Yes | Injected | 7 mg.kg−1 | N/A | ↔ |
| Dandekar et al. (2018) | mTOR | Brain | Rat | No | Injected | 6/9 mg.kg−1 | N/A | ↔ |
| Dandekar et al. (2018) | mTOR-p | Brain | Rat | No | Injected | 6/9 mg.kg−1 | N/A | ↔ |
| Fukuda et al. (2002) | NMDA-p | Brain | Rat | Yes | Inhaled | 79% | 20 min | ↓ |
| Shu et al. (2010) | p53 | Brain | Rat | Yes | Inhaled | 70% | 2 h | ↓ |
| Vizcaychipi et al. (2011) | PI3K | Brain | Mouse | Yes | Inhaled | 70% | 20 min | ↔ |
| Fan et al. (2021) | PI3K | Spinal cord | Rat | Yes | Inhaled | 50% | 2 h | ↔ |
| Fan et al. (2021) | PI3K-p | Spinal cord | Rat | Yes | Inhaled | 50% | 2 h | ↑ |
| Dandekar et al. (2018) | PKC | Brain | Rat | No | Injected | 6/9 mg.kg−1 | N/A | ↔ |
| Dandekar et al. (2018) | PKC-p | Brain | Rat | No | Injected | 6/9 mg.kg−1 | N/A | ↔ |
Direction of effect (achieved statistical significance): ↑–Increased, ↓–Reduced, ↔–No change. Increases highlighted green. Reductions highlighted red.