Table 7.
Messenger RNA summary.
| References | Method quantification | mRNA | Tissue | Species | Injury model | Route xenon | Xenon dose | Xenon duration | Direction of effect |
|---|---|---|---|---|---|---|---|---|---|
| Cattano et al. (2008) | RT PCR | Akt | Brain | Rat | No | Inhaled | 75% | 2 h | ↓ |
| Cattano et al. (2008) | RT PCR | JNKK1 | Brain | Rat | No | Inhaled | 75% | 2 h | ↑ |
| Cattano et al. (2008) | RT PCR | ADNP | Brain | Rat | No | Inhaled | 75% | 2 h | ↑ |
| Valleggi et al. (2008) | RT PCR | PI5P4Kβ | Brain | Rat | No | Inhaled | 75% | 2 h | ↑ |
| Valleggi et al. (2008) | RT PCR | Prothymosin α | Brain | Rat | No | Inhaled | 75% | 2 h | ↑ |
| Valleggi et al. (2008) | RT PCR | Rab14 | Brain | Rat | No | Inhaled | 75% | 2 h | ↑ |
| Valleggi et al. (2008) | RT PCR | SAP 102 | Brain | Rat | No | Inhaled | 75% | 2 h | ↑ |
| Valleggi et al. (2008) | RT PCR | Similar to DNER | Brain | Rat | No | Inhaled | 75% | 2 h | ↑ |
| Metaxa et al. (2014) | RT PCR | MMP-9 | Brain | Rats | Yes | Inhaled | 50% | 45 min | ↓ |
| Zhao et al. (2018) | RT PCR | CLIC-4 | Brain | Rats | Yes | Inhaled | 50% | 3 h | ↓ |
| Filev et al. (2021) | Multiplex | Hmox1 | Brain | Rat | Yes | Inhaled | 75% | 1 h | ↑ |
| Filev et al. (2021) | Multiplex | Irf1 | Brain | Rat | Yes | Inhaled | 75% | 1 h | ↑ |
| Filev et al. (2021) | Multiplex | Myd88 | Brain | Rat | Yes | Inhaled | 75% | 1 h | ↑ |
| Filev et al. (2021) | Multiplex | S100A8 | Brain | Rat | Yes | Inhaled | 75% | 1 h | ↑ |
| Filev et al. (2021) | Multiplex | Tlr2 | Brain | Rat | Yes | Inhaled | 75% | 1 h | ↑ |
Direction of effect (achieved statistical significance): ↑–Increased, ↓–Reduced, ↔–No change. Increases highlighted green. Reductions highlighted red.