Table 8.
Injury quantification summary.
| References | Cell line/ tissue | Species (receptor) | Xenon dose | Additive | Target | Outcome reported | Xenon protection (no additive) | Xenonprotection (additive present) |
|---|---|---|---|---|---|---|---|---|
| Petzelt et al. (2003) | Cortical neurones | Rats | 100% | BAPTA | Ca2+ signaling | LDH release | + | − |
| Petzelt et al. (2004) | Phaeochromocytoma cells | Rats | 100% | BAPTA | Ca2+ signaling | LDH release | + | − |
| Petzelt et al. (2003) | Cortical neurones | Rats | 100% | KN-93 | Ca2+ signaling | LDH release | + | + |
| Bantel et al. (2009) | Neuronal-glial coculture | Mouse | 75% | Tolbutamide | KATP | Cell viability | + | − |
| Banks et al. (2010) | Hippocampal brain slice | Mouse | 50% | Glycine | NMDA | Normalized injury | + | − |
| Lavaur et al. (2016) | Cortical/septal cultures | Rats | 75% | Glycine | NMDA | Survival rate | + | + |
| Koziakova et al. (2019) | hippocampal brain slice | Mouse | 50% | Glycine | NMDA | Normalized injury | + | − |
| Harris et al. (2013) | Hippocampal brain slice | Mouse | 50% | Glycine | NMDA | Normalized injury | + | − |
| Ma et al. (2006) | Neuronal culture | Rats | 75% | Cyclohexamide | Protein synthesis | LDH release | + | − |
+ (green filled box)—xenon provided neuroprotection vs. control condition.
− (red filled box)—xenon did not provide protection vs. control condition.