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. 2023 Jul 14;14:1148595. doi: 10.3389/fimmu.2023.1148595

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Copyright © 2023 Lupi, Bordin, Sales, Colaianni, Vitiello, Biscontin, Reale, Garzino-Demo, Antonini, Ottaviano, Mucignat, Parolin, Calistri and De Pittà

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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miRNAs expression profiling. (A) Unsupervised hierarchical clustering analysis by using the 210 detected miRNAs. Patients are clearly separated from healthy controls, but not according to the severity of the olfactory symptoms. (B) Venn diagram of differentially expressed miRNAs resulting from the comparisons between persistent and no olfactory symptoms patients with respect to healthy controls. Most of differentially expressed miRNA are the same in both comparisons. Heatmap representing differentially expressed miRNAs of two different comparisons: persistent olfactory symptoms (C) and no olfactory symptoms (D) patients with respect to healthy controls. Most of miRNAs are under expressed after SARS-CoV-2 infection. A complete list of differentially expressed miRNAs is provided in the Supplementary Materials ( Supplementary Tables 2 , 3 ).