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. 2023 Jul 19;24(14):11667. doi: 10.3390/ijms241411667

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© 2023 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Effect of low-molecular-weight cervi cornu collagen (NP-2007) on morphological and histopathological changes from knee joint tissue of monosodium iodoacetate (MIA)-induced osteoarthritis (OA) rats. (A) Experimental scheme of MIA-induced OA model in rats. Vehicle, NP-2007 (50, 100, 200 mg/kg), or methyl sulfonyl methane (MSM) (300 mg/kg) were orally administered for three weeks. Morphological and histopathological analysis showing the effect of NP-2007 on knee joint tissue of MIA-induced OA rats. Representative (B) morphological image of the knee joint tissues measured using microcomputed tomography (micro-CT). The representative histopathological images of (C) hematoxylin and eosin (H&E) and (D) safranin O staining. Magnification: 40×.