Figure 10.

DSS and probiotic effects on presynaptic or postsynaptic protein levels in the brains of wild type and App^NL-G-F mice. After 8 weeks of probiotic feeding, the temporal cortices of (A) wild type and (B) App^NL-G-F mice treated with or without DSS were lysed, and the proteins were resolved by SDS-PAGE for Western blot analysis using antibodies against PSD95, synaptophysin, and GAPDH (loading control). Data from Western blots are graphed as mean ± SEM of PSD95 or synaptophysin values normalized to their respective GAPDH. One-way ANOVA followed by uncorrected Fisher’s LSD test was used to determine statistical differences; * p < 0.05 and ** p < 0.001.