Table 2.
Demographic, clinical, and exposure characteristics of patients with candidemia in seven centres in Colombia, 2016–2021.
| Characteristic | All n = 512 |
C. auris n = 134 |
CNA 1 n = 378 |
SMD 2 |
|---|---|---|---|---|
| Male gender (%) | 317 (61.9) | 86 (64.2) | 231 (61.1) | 0.063 |
| Age, years (mean (SD 3)) | 68.5 (17.7) | 54.3 (17.1) | 60.0 (17.6) | 0.331 |
| COVID-19 (%) | 166 (32.4) | 47 (35.1) | 119 (31.5) | 0.076 |
| Congestive heart failure (%) | 43 (8.3) | 7 (5.2) | 36 (9.5) | 0.165 |
| Cardiovascular Disease (%) | 195 (38.0) | 44 (32.8) | 151 (39.9) | 0.148 |
| COPD (%) | 66 (12.8) | 12 (9.0) | 54 (14.3) | 0.167 |
| Chronic kidney disease (%) | 34 (6.6) | 14 (10.4) | 20 (5.3) | 0.192 |
| Diabetes (%) | 97 (18.9) | 30 (22.4) | 67 (17.7) | 0.117 |
| Cancer (%) | 32 (6.25) | 13 (9.7) | 19 (5.0) | 0.180 |
| Abdominal surgery (%) | 58 (11.3) | 17 (12.3) | 41 (10.8) | 0.319 |
| Bacteremia 14 days prior (%) | 127 (24.8) | 40 (29.8) | 87 (23.0) | 0.155 |
| Broad-spectrum antibiotic 14 days prior | 477 (93.2) | 132 (98.5) | 345 (91.8) | 0.333 |
| Charlson comorbidity index (mean (SD)) | 2.6 (2.2) | 2.4 (2.1) | 2.7 (2.2) | 0.184 |
| SOFA (mean (SD)) | 7.96 (3.9) | 7.42 (3.3) | 8.15 (4.07) | 0.196 |
| Intensive Care Unit (%) | 267 (52.2) | 64 (47.8) | 203 (53.7) | 0.119 |
| Time to candidaemia (mean (SD)) | 20.0 (16.0) | 22.9 (16.4) | 19.1 (15.9) | 0.231 |
| Referred from another hospital (%) | 81 (15.8) | 21 (15.7) | 60 (15.9) | 0.006 |
| Mechanical ventilation (%) | 316 (61.7) | 83 (61.9) | 233 (61.6) | 0.006 |
| Total parenteral nutrition (%) | 120 (23.4) | 33 (24.6) | 87 (23.0) | 0.038 |
| Dialysis (%) | 73 (14.2) | 18 (13.4) | 55 (14.6) | 0.032 |
| Hypotension (%) | 48 (9.3) | 15 (11.1) | 33 (8.7) | 0.082 |
| Sepsis (%) | 349 (68.1) | 100 (74.6) | 249 (65.8) | 0.192 |
| Septic shock (%) | 140 (27.3) | 32 (23.8) | 108 (28.5) | 0.107 |
| Central venous catheter (%) | 444 (86.7) | 117 (87.3) | 327 (86.5) | 0.024 |
| FiO2 (median (RIQ)) | 40 (32–50) | 40 (32–50) | 40 (32–50) | 0.008 |
| PaO2/FiO2 4 (median (RIQ)) | 188 (140–256) | 202 (143–270) | 185 (134–249) | 0.522 |
1 CNA: Candida non-auris. 2 SMD: Standardized mean difference. 3 SD: standard deviation, 4 PaO2/FiO2: ratio of arterial partial pressure of oxygen over the fraction of inspired oxygen.