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Synthesis of 1,3,4-oxadiazoles 3,4 and 1,3,4-thiadiazoles 5,6. Reagents and conditions: (i) EDCI, HOBt, DMF, r.t 1–4 h, then r.t. 24 h or 60 °C 2–24 h or reflux 24 h; (ii) POCl3, reflux 3–6 h or 45° 24–48 h; (iii) Lewesson’s reagent, pyridine, reflux, 4–48 h.
