Table 3.
Half-maximal inhibitory concentration values (IC50) a in µM of derivatives 3b, 3e, 4c, 5b, 6c on pancreatic cancer cells.
| PDAC Cell Lines |
1,3,4-Oxadiazoles | 1,3,4-Thiadiazoles | |||
|---|---|---|---|---|---|
| 3b | 3e | 4c | 5b | 6c | |
| BxPC-3 | 2.1 ± 0.006 | ND b | 3.3 ± 2.4 | 2.7 ± 0.68 | ND |
| Panc-1 | 2.5 ± 0.55 | ND | 13.4 ± 3.2 | 3.5 ± 0.01 | 11.5 ± 1.2 |
| Panc-1-GR | 8.0 ± 2.8 | ND | 10.8 ± 1.4 | 9.8 ± 0.05 | ND |
| Suit-2 | 1.4 ± 0.74 | 9.4 ± 4.3 | ND | 1.9 ± 0.27 | 4.1 ± 0.9 |
| Capan-1 | 2.6 ± 0.62 | ND | 10.8 ± 0.67 | 3.3 ± 0.61 | 12.6 ± 1.3 |
| PaTu-T | 3.2 ± 0.42 | ND | 9.7 ± 0.17 | 3.4 ± 0.06 | 3.8 ± 1.8 |
| PDAC-3 | 8.1 ± 0.14 | 23 ± 0.06 | ND | 10.6 ± 0.04 | ND |
a SEM: Standard Error of the Mean. b ND not determined.