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. 2023 Jul 10;13(7):1116. doi: 10.3390/jpm13071116

Table 1.

Diagnostic and non-diagnostic symptoms of mast cell activation syndrome [125,126].

Organ/System Diagnostic Symptoms Non-Diagnostic Symptoms
Cutaneous Flushing, pruritus, hives, angioedema Dermographism, urticaria, rashes, edema/migratory edema, alopecia, poor healing, onychodystrophy
Respiratory Shortness of breath, laryngeal edema, wheezing, hypoxia, nasal congestion, sneezing Dyspnea, asthma, cough
Gastrointestinal Vomiting, abdominal cramps, diarrhea Constipation, alternating diarrhea/constipation, gastroesophageal reflux, dyspepsia, dysphagia, heartburn, nausea, elevated transaminases, hepatomegaly, multiple chemical/food sensitivity
Cardiovascular Hypotension, syncope, collapse, incontinence Chest pain, palpitations/dysrhythmias, systolic hypertension (mild/moderate), tachycardia
General Fatigue, weight loss or gain, obesity, fever, chills, sweats, frequent or odd infections, heat and/or cold intolerance
Allergologic Multiple/odd drug reactions
Neuro-psychiatric Headaches, migraines, cognitive disfunction/brain fog, insomnia, anxiety, depression, dysautonomia symptoms (POTS), tremor, paresthesia
Musculoskeletal Myalgia, arthralgia, joint hypermobility, fibromyalgia-type pain
Urogenital Dysuria, frequency, urgency, prostatitis, polycystic ovarian syndrome, endometriosis
Ophthalmologic Eye irritation, conjunctivitis, visual anomalies
Ears, nose, throat Tinnitus, hearing loss, rhinitis, sinusitis, sore throat, oral irritation/sores
Hematological Easy bleeding/bruising
Lymphatic system Adenopathy/adenitis
Stomatological Dental deterioration