TABLE 1.
Inhibition of influenza virus replication by CL compounds
| Compound | IC50 (μg/ml)a
|
||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| A/WSN/33b | A/FM/47b | A/Japan/305/57c | A/Japan/170/62c | A/Hong Kong/8/68d | A/Victoria/3/75d | B/GL | FM mutant
|
||||
| Amr | Amr 61917r | 61917r-A | 62554r-A | ||||||||
| CL 61917 | 2 | 1.5 | 0.4 | 1 | 25 | 25 | 75 | 0.8 | 25 | 75 | 50 |
| CL 62554 | 12 | 7 | ND | ND | ND | ND | ND | 4 | ND | 75 | 50 |
| CL 385319 | 0.1 | 0.3 | ND | 0.7 | 25 | 25 | 50 | 0.15 | 2 | 50 | ND |
| Amantadine | ND | 0.05 | ND | ND | ND | ND | ND | ND | ND | 0.05 | 0.05 |
a
Determined by plaque reduction assays. For WSN virus, we also performed ELISAs, which gave IC50s identical to those obtained by plaque assay. ND, not done.
b
H1N1 strain.
c
H2N2 strain.
d
H3N2 strain.