Figure 3.

Platelet GPIb/IX/V’s structure. The largest subunit of the complex is GPIbα, comprising leucine-rich repeats in the ligand-binding domain, a negatively charged domain, a macroglycopeptide domain, a mechanosensitive domain, and the trigger sequence. GPIbα and GPIbβ are connected through disulfide bonds. The transmembrane domain facilitates close interaction with GPIbβ and GPIX, forming a stable parallel structure. GPV weakly interacts with GPIb-IX through polar interactions and can potentially be replaced by other receptors.