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. 2023 Jul 28;9(30):eadg7480. doi: 10.1126/sciadv.adg7480

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Fig. 4. — (A) Two views of an AlphaFold2 model predicting how CENP-A^N interacts with CENP-QU. The major site of interaction involves CENP-A^END with CENP-QU^Foot and CENP-QU coiled coil. CENP-A^N is colored with a sequence conservation score. (B) Cryo-EM map of the CENP-A^N:CENP-OPQU+ (COMA) complex. (C) Ribbons representation of the COMA complex. In this structure, the CENP-QU^Foot and adjacent coiled coil, including the CENP-A^END binding site of CENP-QU, are mobile and not visible in the cryo-EM map. These are shown schematically. (D) Structure of CENP-OPQU+ in the context of CCAN superimposed onto the COMA complex. This shows the conformational change of the N-terminal region of Nkp1-Nkp2 exposing the CENP-A^END binding site on CENP-QU (mobile) in the free CENP-OPQU+ complex (movie S2).