Fig. 5. Schematic of the point centromere-kinetochore of S. cerevisiae.

In this model, the holo–inner kinetochore complex (two CCAN protomers) together with two additional CENP-A^END–binding CENP-QU modules form a total of eight Ndc80c connections to the spindle microtubule. CENP-QU:CENP-A^END:MIND:Ndc80c modules represent components of the CENP-QU pathway described in Fig. 4. To which degree the CCAN and CENP-QU pathways overlap physically and temporally at the centromere remains to be determined. C^N, U^N, and T^N refer to the N-terminal motifs of CENP-C, CENP-U, and CENP-T, respectively, which bind MIND (C^N and U^N) and Ndc80 (T^N).