Table 2.
Metabolites Significantly Associated With All 3 Definitions of HFpEF*
| Pathway | Subpathway | Metabolite |
|---|---|---|
| Lipid | Lysolipid | 1‐arachidonoyl‐GPE* (20:4)* |
| 1‐docosahexaenoylglycerophosphoethanolamine* | ||
| 2‐stearoylglycerophosphoethanolamine* | ||
| 1‐stearoyl‐GPE (18:0) | ||
| 2‐arachidonoyl‐GPE* (20:4)* | ||
| 1‐myristoyl‐GPC (14:0) | ||
| Fatty acid, dicarboxylate | azelate (nonanedioate; C9) | |
| Mole % total fatty acid | TL18:3n6 (g‐linolenic acid) | |
| Monoacylglycerol | 2‐docosahexaenoylglcyerol* | |
| 1‐arachidonylglycerol | ||
| Energy | TCA cycle | citrate |
| alpha‐ketoglutarate | ||
| Amino acid | Methionine, cysteine, SAM, and taurine metabolism | S‐methylcysteine |
| Lysine metabolism | N6‐acetyllysine | |
| Xenobiotics | Food component/plant | methyl glucopyranoside (alpha+beta) |
GPC indicates glycerophosphocholine; GPE, glycerophosphoethanolamine; SAM, S‐Adenosyl methionine; and TCA, tricarboxylic acid cycle.
*
Covariates: age, sex, diabetes, hypertension, body mass index, and liver fibrosis stage.