Table 1.
Baseline Characteristics of Study Participants With Different Baseline Platelet Counts Stratified by HS‐CRP Levels
| Characteristics* | HS‐CRP <4.8 mg/L | P trend value | HS‐CRP ≥4.8 mg/L | P trend value | ||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Quartile 1 | Quartile 2 | Quartile 3 | Quartile 4 | Quartile 1 | Quartile 2 | Quartile 3 | Quartile 4 | |||
| No. of subjects | 604 | 614 | 630 | 602 | 197 | 215 | 172 | 233 | ||
| Demographics | ||||||||||
| Age, y | 64.0 (11.0) | 61.5 (10.8) | 61.0 (9.9) | 59.4 (10.9) | <0.001 | 66.7 (10.7) | 64.7 (10.7) | 65.8 (10.7) | 64.5 (11.0) | 0.106 |
| Men, N (%) | 449 (74.3) | 416 (67.8) | 399 (63.3) | 305 (50.7) | <0.001 | 143 (72.6) | 153 (71.2) | 102 (59.3) | 126 (54.1) | <0.001 |
| Current cigarette smoking, N (%) | 242 (40.1) | 223 (36.3) | 247 (39.2) | 205 (34.1) | 0.088 | 78 (39.6) | 91 (42.3) | 56 (32.6) | 75 (32.2) | 0.031 |
| Current alcohol drinking, N (%) | 204 (33.8) | 215 (35.0) | 200 (31.8) | 166 (27.6) | 0.010 | 61 (31.0) | 74 (34.4) | 44 (25.6) | 57 (24.5) | 0.040 |
| Time to randomization after admission, h | 10 (4–24) | 12 (5–24) | 10 (5–24) | 12 (5–24) | 0.006 | 7 (4–24) | 10 (5–24) | 12 (5–24) | 7 (3–20) | 0.461 |
| Medical history, N (%) | ||||||||||
| Hypertension | 467 (77.3) | 490 (79.8) | 484 (76.8) | 473 (78.6) | 0.927 | 150 (76.1) | 176 (81.9) | 143 (83.1) | 189 (81.1) | 0.220 |
| Hyperlipidemia | 44 (7.3) | 47 (7.7) | 41 (6.5) | 50 (8.3) | 0.696 | 12 (6.1) | 9 (4.2) | 8 (4.7) | 18 (7.7) | 0.838 |
| Diabetes | 122 (20.2) | 108 (26.0) | 97 (15.4) | 89 (14.8) | 0.007 | 29 (14.7) | 36 (16.7) | 33 (19.2) | 55 (23.6) | 0.014 |
| Clinical features | ||||||||||
| Baseline NIHSS score | 4 (2–7) | 4 (2–7) | 4 (2–7) | 4 (2–7) | 0.686 | 6 (3–11) | 6 (3–10) | 7 (3–11) | 6 (4–10) | 0.980 |
| BMI, kg/m2 | 24.8 (3.1) | 24.9 (3.0) | 24.9 (3.2) | 24.9 (3.0) | 0.527 | 24.9 (3.2) | 24.9 (3.1) | 25.0 (3.3) | 25.3 (3.3) | 0.161 |
| Systolic BP, mm Hg | 167.1 (17.6) | 166.1 (16.8) | 165.6 (15.6) | 165.0 (17.0) | 0.030 | 166.9 (17.6) | 167.4 (17.1) | 167.7 (18.0) | 167.5 (16.8) | 0.704 |
| Diastolic BP, mm Hg | 96.5 (11.2) | 96.7 (11.3) | 96.6 (9.8) | 96.7 (11.5) | 0.829 | 95.7 (10.9) | 97.7 (11.3) | 97.3 (11.7) | 96.1 (11.5) | 0.920 |
| Triglycerides, mmol/L | 1.4 (1.0–2.1) | 1.5 (1.0–2.0) | 1.5 (1.1–2.2) | 1.6 (1.1–2.2) | 0.029 | 1.3 (0.9–2.0) | 1.4 (1.0–2.1) | 1.5 (1.1–2.0) | 1.4 (1.0–2.1) | 0.379 |
| TC, mmol/L | 4.7 (4.0–5.4) | 5.0 (4.3–5.6) | 5.1 (4.3–5.8) | 5.3 (4.5–5.9) | <0.001 | 4.7 (4.1–5.5) | 4.8 (4.3–5.6) | 5.1 (4.6–5.9) | 5.1 (4.3–5.9) | 0.001 |
| LDL‐C, mmol/L | 2.6 (2.1–3.3) | 2.9 (2.3–3.5) | 2.9 (2.3–3.6) | 3.0 (2.4–3.6) | <0.001 | 2.7 (2.1–3.4) | 2.8 (2.3–3.5) | 3.0 (2.4–3.5) | 3.0 (2.4–3.6) | <0.001 |
| HDL‐C, mmol/L | 1.2 (1.0–1.4) | 1.2 (1.0–1.5) | 1.2 (1.0–1.5) | 1.3 (1.1–1.5) | 0.006 | 1.3 (1.0–1.5) | 1.2 (1.0–1.5) | 1.3 (1.0–1.5) | 1.2 (1.0–1.5) | 0.589 |
| Blood glucose, mmol/L | 5.8 (5.1–7.5) | 5.7 (5.0–6.8) | 5.7 (5.0–7.0) | 5.6 (5.0–6.8) | 0.059 | 5.7 (5.1–7.1) | 6.0 (5.2–7.3) | 6.2 (5.4–8.1) | 6.5 (5.5–8.2) | 0.009 |
| White blood cell, 109/L | 5.9 (4.9–7.1) | 6.3 (5.2–7.5) | 6.9 (5.7–8.2) | 7.4 (6.1–8.7) | <0.001 | 6.9 (5.5–8.9) | 7.5 (6.1–9.2) | 8.4 (6.4–8.4) | 8.5 (6.8–10.0) | <0.001 |
| Ischemic stroke subtype, N (%) | ||||||||||
| Thrombotic | 470 (77.8) | 471 (76.7) | 495 (78.6) | 462 (76.7) | 0.866 | 134 (68.0) | 169 (78.6) | 130 (75.6) | 168 (72.1) | 0.598 |
| Embolic | 26 (4.3) | 22 (3.6) | 17 (2.7) | 25 (4.2) | 0.686 | 20 (10.2) | 15 (7.0) | 9 (12.2) | 30 (12.9) | 0.333 |
| Lacunar | 120 (19.9) | 134 (21.8) | 140 (22.2) | 131 (21.8) | 0.414 | 46 (23.4) | 37 (17.2) | 38 (22.1) | 38 (16.3) | 0.167 |
| Randomized antihypertensive, N (%) | 302 (50.0) | 294 (47.9) | 336 (53.3) | 279 (46.4) | 0.561 | 107 (54.3) | 109 (50.7) | 92 (53.5) | 118 (50.6) | 0.583 |
Quartile 1, platelet count <171×109/L; quartile 2, 171×109/L≤platelet count<209×109/L; quartile 3, 209×109/L≤platelet count<248×109/L; and quartile 4, platelet count ≥248×109/L. BMI indicates body mass index; BP, blood pressure; HDL‐C, high‐density lipoprotein cholesterol; HS‐CRP, high‐sensitivity C‐reactive protein; LDL‐C, low‐density lipoprotein cholesterol; NIHSS, National Institutes of Health Stroke Scale; and TC, total cholesterol.
*
Continuous variables are expressed as mean (SD) or median (interquartile range). Categorical variables are expressed as frequency (percentage).