Table 4.
WM tracts with significantly higher FA values in physically active patients with high vascular burden compared with non-physically active controls with high vascular burden (FWE p < 0.05).
| MNI coordinates of local maxima | WM tracts | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| Clusters | Voxels | Value | p-value | X | Y | Z | JHU-ICBM-DTI − 81 WM labels | JHU-WM tractography atlas | Talairach Daemon |
| 1 | 15,916 | 4.85 | 0.012 | −8 | −18 | −2 | Unclassified | Left anterior thalamic radiation | |
| 4.73 | 0.012 | −22 | −8 | 14 | Left posterior limb of internal capsule | ||||
| 4.65 | 0.012 | −15 | −26 | 13 | Unclassified | Left anterior thalamic radiation | |||
| 4.63 | 0.012 | −29 | −33 | 13 | Left retrolenticular part of internal capsule | ||||
| 4.5 | 0.012 | −12 | −20 | 6 | Unclassified | Left anterior thalamic radiation | |||
| 4.41 | 0.012 | −28 | −18 | 17 | Left external capsule | Left corticospinal tract | |||
| 2 | 12,725 | 5.03 | 0.012 | 27 | −30 | 17 | Right retrolenticular part of internal capsule | ||
| 4.75 | 0.012 | 27 | −26 | 15 | Right retrolenticular part of internal capsule | ||||
| 4.66 | 0.012 | 50 | 0 | −12 | Unclassified | Right inferior longitudinal fasciculus | |||
| 4.39 | 0.012 | 27 | −28 | 18 | Right retrolenticular part of internal capsule | ||||
| 4.3 | 0.012 | 27 | −30 | 23 | Right posterior corona radiata | ||||
| 4.2 | 0.012 | 31 | −34 | 15 | Right retrolenticular part of internal capsule | ||||
| 3 | 3,085 | 4.43 | 0.035 | 8 | −67 | −21 | Unclassified | Right cerebellum | |
| 4.09 | 0.035 | 10 | −42 | −36 | Right inferior cerebellar peduncle | ||||
| 3.92 | 0.035 | −5 | −69 | −22 | Unclassified | Left cerebellum | |||
| 3.9 | 0.035 | 24 | −61 | −20 | Unclassified | Right cerebellum | |||
| 3.78 | 0.035 | 11 | −71 | −22 | Unclassified | Right cerebellum | |||
| 3.73 | 0.035 | 24 | −57 | −22 | Unclassified | Right cerebellum | |||
| 4 | 2061 | 4.44 | 0.034 | 8 | −9 | 5 | Unclassified | Right anterior thalamic radiation | |
| 4.42 | 0.034 | 8 | −18 | 8 | Unclassified | Right anterior thalamic radiation | |||
| 4.33 | 0.034 | 20 | −30 | 0 | Unclassified | Right cerebrum, sub-lobar, extra-nuclear, WM | |||
| 4.3 | 0.034 | 15 | −16 | 8 | Unclassified | Right cerebrum, sub-lobar, extra-nuclear, WM | |||
| 4.27 | 0.034 | 20 | −28 | 4 | Unclassified | Right cerebrum, sub-lobar, extra-nuclear, WM | |||
| 4.17 | 0.034 | 8 | −19 | 4 | Unclassified | Right anterior thalamic radiation | |||
| 5 | 886 | 4.41 | 0.045 | 8 | −29 | −32 | Pontine crossing tract (a part of MCP) | Right corticospinal tract | |
| 4.29 | 0.045 | 6 | −28 | −33 | Right corticospinal tract | Right corticospinal tract | |||
| 4.22 | 0.045 | 8 | −31 | −35 | Pontine crossing tract (a part of MCP) | Right corticospinal tract | |||
| 4.03 | 0.045 | 8 | −31 | −33 | Pontine crossing tract (a part of MCP) | Right corticospinal tract | |||
| 3.77 | 0.045 | 7 | −27 | −30 | Right corticospinal tract | Right corticospinal tract | |||
| 3.39 | 0.045 | 5 | −31 | −32 | Pontine crossing tract (a part of MCP) | Right corticospinal tract | |||
Only clusters with > 200 voxels are listed; Talairach Daemon atlas was used when regions were either labeled as unclassified or undefined by JHU atlas; MCP = middle cerebellar peduncle; Values in bold indicate p values < 0.05.