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. 2023 Jul 14;14:1182553. doi: 10.3389/fimmu.2023.1182553

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Copyright © 2023 Zhang, Audiger, Chopin and Nutt

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Transcription factors controlling DC specification and function. The figure highlights the development of cDCs subtypes and pDCs from the shared common dendritic cell progenitors (CDP). Some other DCs subtypes (DC3) have also been reported recently in mouse and human and derive from monocyte-dendritic cell progenitors (MDP). The common lymphoid progenitor (CLP) generates pDCs but lack cDC potential. Under inflammation, monocytes can differentiate into monocyte-derived (mono)DCs. Each DC subtype has unique surface markers and attributes in regulating immune response. The transcription factors governing DC lineage specification and function are shown.