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. 2023 Jan 17;94(2):564–574. doi: 10.1038/s41390-022-02415-y

Table 3.

Phase-I regression coefficients of the association of early-life adversity measures with infants’ cytokines and steroids.

Outcome SES-D GAD-2 FAD CESD-8 N R2
B Std. B FDR q B Std. B FDR q B Std. B FDR q B Std. B FDR q
TNF-α pg/mL 0.13a 0.28 0.011 0.01 0.14 0.362 −0.01 0.00 0.657 0.00 −0.28 0.407 71 0.10
IL-1β pg/mL 0.10a 0.19 0.033 −0.02 −0.05 0.362 0.00 −0.02 0.863 0.00 −0.04 0.407 142 0.04
IL-6 pg/mL 0.03 0.06 0.524 0.02 0.06 0.362 −0.02 −0.10 0.303 0.01 0.06 0.407 138 0.02
IL-8 pg/mL 0.07 0.14 0.122 −0.01 −0.02 0.438 −0.01 −0.04 0.702 0.01 0.05 0.407 139 0.02
Cortisol pg/mg −0.02 −0.02 0.871 −0.08 −0.15 0.362 0.08a 0.27 0.033 0.03 0.13 0.407 79 0.09
Cortisone pg/mg 0.00 0.00 0.995 0.02 0.08 0.362 0.05a 0.37 0.003 −0.02 −0.21 0.319 79 0.10
DHEA pg/mg 0.16a 0.35 0.011 0.03 0.14 0.362 0.00 0.00 0.982 −0.03 −0.28 0.294 76 0.09

Note: bold values indicate FDR-adjusted significant associations (q < 0.05).

SES-D socioeconomic disadvantage index, CESD-8 Center for Epidemiological Depression scale, GAD-2 Generalized Anxiety Disorder scale, FAD Family Assessment Device, Std. standardized.

aSignificant at 5% bootstrap levels.