Table 2.
Clinical severity, laboratory, and outcome data of the studied groups.
| Studied variables | Sepsis (n = 95) | Severe sepsis (n = 57) | Septic shock (n = 28) | p value |
|---|---|---|---|---|
| Age (month) | 12 (4.2–44.2) | 20 (11.3–42) | 24 (3–120) | 0.783 |
| Male, sex | 38 (40%) | 25 (43.8%) | 12 (42.8%) | 0.712 |
| Clinical severity | ||||
| MV needed | 9 (9.5%) | 15 (26.3%) | 21 (75.0%) | 0.001* |
| MV duration (h) | 96 (40–158) | 120 (48–169) | 144 (59–180) | 0.047* |
| Use of vasopressor | 10 (10.5%) | 15 (26.3%) | 28 (100%) | <0.001* |
| P-MODS | 0 (0–1) | 2 (0–3) | 7 (3–9) | <0.001* |
| DIC score | 2 (0–2) | 3 (1–3) | 5 (3–5) | <0.001* |
| pSOFA | 5 (4–7) | 8.5 (7–10.2) | 9 (7–12) | 0.002* |
| Laboratory data | ||||
| WBCs (1000/µl) | 14.8 (8.6–19.9) | 18.7 (8.3–21.2) | 17.8 (4.3–20.9) | 0.909 |
| Platelets (1000/µl) | 315 (256–402) | 237 (190–540) | 219 (118–263) | 0.968 |
| Creatinine (mg/dl) | 0.6 (0.3–0.9) | 0.55 (0.57–1.8) | 0.90 (0.60–2.1) | 0.048* |
| CRP (mg/l) | 32 (12–48) | 34 (17.5–48) | 48 (26–84) | 0.019* |
| PSP (ng/ml) | 19.7 (10.2–49.2) | 68.4 (55.2–100.6) | 143.0 (83.6–230.1) | <0.001* |
| Copeptin (ng/ml) | 2.57 (2.33–3.09) | 5.08 (4.60–5.65) | 6.57 (6.50–7.31) | <0.001* |
| Apolipoprotein A-V (ng/ml) | 1500 (1500–1600) | 1154.5 (861.5–1500) | 842.1 (505.8–951.6) | <0.001* |
| Outcome | ||||
| PICU stay/day | 6.5 (5–10) | 8.5 (9–16) | 8 (5–17) | 0.148 |
| Hospital stay/day | 15 (10–25) | 16 (12–31) | 17 (13–29) | 0.552 |
| PRISM mortality risk % | 9 (9–15) | 26.8 (19–36.5) | 45.5 (39–70.5) | <0.001* |
| PIM2 mortality risk % | 6.9 (4.5–11.6) | 17.5 (4.19–23.03) | 42.6 (5.21–65) | <0.001* |
| Mortality | 5 (5.3%) | 9 (15.8%) | 15 (53.6%) | 0.005* |
Data are expressed as number (%) or median (IQR).
MV mechanical ventilation, P-MODS Pediatric-Multiple Organ Dysfunction, DIC disseminated intravascular coagulation, pSOFA Pediatric Sequential Organ Failure Assessment Score, WBC white blood cells, CRP C-reactive protein, PSP pancreatic stone protein, PICU Pediatric Intensive Care Unit, PRISM Pediatric Risk of Mortality, PIM2 Pediatric Index of Mortality-2, PSP pancreatic stone protein.
*Statistically significant.