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. 2022 Nov 24;23(4):61–72. doi: 10.1038/s41397-022-00297-1

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — a The PPARA pathway activity score difference of the 1390 CMAP gene expressoin instances. The y-axis shows the difference between the activity score in the treatment and the paired control for each instance. The x-axis shows the instances ordered by decreasing corresponding activity score difference. b The connectivity score of the 1390 CMAP gene expression instances. The y-axis shows the connectivity score and the x-axis shows the instances ordered by increasing corresponding connectivity score. c A Venn diagram showing the intersection between the top 50 drugs identified by the activity score difference and the activity score.