Table 3.

The intersection of top 50 drugs by activity (Method 1) and connectivity (Method 2) scores on PPARA pathway.

Drug name	Dose (µM)	Na	Rank by		Activity score (Method 1)			Connectivity score (Method 2)
			Activity score difference (ASd)b	Connectivity score	Treatment (ASt)	Control (ASc)	Difference (ASd)
Anisomycin	15	2	1	15	2.71	−0.26	2.96	−0.66
Cephaeline	6	3	2	48	3.01	0.61	2.4	−0.58
Pararosaniline	10	1	3	4	2.52	0.3	2.22	−0.73
Cycloheximide	14.2	2	6	39	2.05	−0.02	2.08	−0.61
Monensin	10.9	1	17	21	0.34	−1.23	1.57	−0.64
Wortmannin	1	2	18	44	2.75	1.18	1.56	−0.6
Raloxifene	0.1	1	24	47	0.72	−0.66	1.38	−0.58
Prednisolone	1	1	25	8	0.65	−0.73	1.38	−0.71
Valinomycin	0.1	2	34	29	1.11	−0.09	1.2	−0.62
Oligomycin	1	1	37	31	0.51	−0.63	1.15	−0.62
Mepacrine	7.8	1	44	14	0.93	−0.1	1.03	−0.66
5186324	2	1	47	20	1.31	0.3	1.01	−0.65
5162773	7	1	48	30	1.31	0.3	1.01	−0.62

^aThe number of experiments.

^bActivity difference = activity score in treatment (ASt) − activity score in control (ASc).