Table 4.

The top 10 drugs identified by Method 2 for downregulating the FOXM1 and upregulating the PPARA pathways simultaneously.

Rank	Drug name	Dose (µM)	Na	Up score	Down score	Connectivity score (Method 2)
1	MG-262	0.1	1	−0.55	0.19	−0.91
2	Clotrimazole	50	1	−0.32	0.34	−0.82
3	MG-132	21	1	−0.52	0.14	−0.81
4	Hycanthone	11	2	−0.44	0.15	−0.73
5	Celastrol	3	1	−0.43	0.15	−0.72
6	Ciclopirox	15	2	−0.46	0.11	−0.71
7	Withaferin A	1	2	−0.39	0.18	−0.7
8	Cephaeline	6	3	−0.35	0.19	−0.67
9	Pararosaniline	10	1	−0.31	0.23	−0.67
10	Puromycin	7	2	−0.34	0.19	−0.66

^aThe number of the MCF7 cell samples treated by the drug at the same dose.