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. 2023 Jul 27;24(8):1382–1390. doi: 10.1038/s41590-023-01558-2

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — a, UMAP projection of integrated human brain biopsy microglia (left) and iMGL profiles (right). Cells are colored by dataset. b, UMAP projection of integrated human brain biopsy microglia and iMGL profiles. Cells are colored by BB/iMGL joint cluster. c, Proportion of cells per joint cluster from each source of data (human brain biopsy microglia or iMGLs), normalized by the proportion of total cells per dataset. d, River plot showing the relationship between joint clusters and the clusters defined in both the iMGL and brain biopsy datasets. Links with fewer than 200 cells have been removed for clarity. e, Heatmap illustrating the relative enrichment significance (as determined by fgsea; Methods) of positively enriched marker genes from each human brain biopsy cluster, within all differentially expressed genes for each iMGL cluster. Prolif, proliferative; NES, normalized enrichment score. *P < 0.05, **P < 0.01, ***P < 0.001.