Fig. 2.

A Preparation of PTX-NPs. PLGA and Paclitaxel were mixed in DCM. The dissolved polymeric solution with Paclitaxel was mixed in 0.2% PVA solution. The mixed solution was homogenized at 80% for 3 min to get a homogeneous solution. After stirring for 4 h, PTX-NPs were centrifuged and harvested after purification. B Steps in paclitaxel coating of catheters. Surface hydroxyl groups (–OH) of catheter activated through oxidation; using APTES solution, NH2 attaches to catheter surface, enabling coating of nanoparticles via EDC-NHS (carbodiimide-hydrochloride)