Fig. 7.

PRRT response in less responsive NET. A Cumulative radiation dose (Gy) to physiological organs and three tumour lesions in the liver. B Absorbed dose (Gy) per GBq injected activity in physiological organs and three tumour lesions in the liver at cycles 1–4 (blue, red, green, and purple bars, respectively). The renal and spleen dose is generally lower for the first couple of cycles than later (although both are relatively stable during treatment) whereas tumour dose decreases and therefore therapeutic index is highest early. C MIP images of Q-SPECT 24-h post cycles 1–4 of LuTate therapy along with administered activity, totalling 38 GBq in 4 cycles