TABLE 1.
CCR5, CCR3, and orphan receptor use by HIVD envelope-pseudotyped viruses
| Virus | Level of infectiona with receptor:
|
|||||||
|---|---|---|---|---|---|---|---|---|
| CCR5 | CCR3 | CXCR4 | APJ | CCR8 | GPR1 | GPR15 | STRL33 | |
| DS | +++ | ++ | − | + | + | − | + | + |
| RC | +++ | + | − | + | + | − | + | − |
| KJ | ++ | − | − | − | − | − | − | − |
| YU-2 | +++ | + | − | − | − | − | + | − |
| BaL | +++ | + | − | + | − | − | − | − |
| NL43 | − | − | ++ | − | − | − | − | − |
| 251 | ++ | − | − | − | − | − | ++ | ++ |
a
Infection was measured in RLU per second. −, less than 1 log unit over background; +, 1 log unit over background; ++, 2 log units over background; +++, 3 log units over background. Background, infection with CD4 alone and no chemokine receptor (see text for details).