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. 2023 Jun 1;50(10):3050–3061. doi: 10.1007/s00259-023-06272-7

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — The area under the time activity curve (AUC) in HT-1080.hFAP A and HEK-293.hFAP B expressed as mean ± standard deviation. These pharmacokinetic data were generated from serial independent biodistribution experiments performed 4, 24, and 72 h post injection. While [¹⁷⁷Lu]Lu-FAPI-46, [¹⁷⁷Lu]Lu-FAPI-46-F1D, and [¹⁷⁷Lu]Lu-FAPI-46-Ibu showed similar AUC values in the two tumor models, [¹⁷⁷Lu]Lu-FAPI-46-EB and [¹⁷⁷Lu]Lu-FAP-2286 exhibited significantly higher AUC values in the HEK-293.hFAP tumor (high FAP expression), compared with the HT-1080.hFAP (low FAP expression)