Table 1.
[177Lu]Lu-FAPI-46 biodistribution results in HT-1080 and HEK-293 xenografts expressed as mean of the % injected activity per gram of tissue (%I.A./g) ± standard deviation (SD) (n = 4–5/group)
Organ | HT-1080 xenografts | HEK-293 xenografts | ||||
---|---|---|---|---|---|---|
4 h | 24 h | 72 h | 4 h | 24 h | 72 h | |
Blood | 0.43 ± 0.04 | 0.03 ± 0.01 | 0.00 ± 0.00 | 0.65 ± 0.08 | 0.03 ± 0.01 | 0.00 ± 0.00 |
Lung | 0.29 ± 0.03 | 0.05 ± 0.02 | 0.03 ± 0.00 | 0.41 ± 0.08 | 0.04 ± 0.01 | 0.01 ± 0.00 |
Liver | 0.29 ± 0.02 | 0.21 ± 0.06 | 0.24 ± 0.05 | 0.35 ± 0.05 | 0.19 ± 0.07 | 0.10 ± 0.04 |
Kidney | 1.19 ± 0.34 | 0.59 ± 0.05 | 0.39 ± 0.12 | 1.33 ± 0.19 | 0.38 ± 0.06 | 0.15 ± 0.10 |
Muscle | 0.58 ± 0.38 | 0.09 ± 0.05 | 0.04 ± 0.03 | 0.49 ± 0.15 | 0.08 ± 0.03 | 0.01 ± 0.00 |
Femur | 2.52 ± 0.38 | 0.61 ± 0.14 | 0.73 ± 0.08 | 2.22 ± 0.58 | 0.55 ± 0.22 | 0.19 ± 0.06 |
hFAP-tumor | 9.63 ± 1.79 | 2.68 ± 0.74 | 1.58 ± 0.37 | 10.34 ± 4.55 | 3.39 ± 1.65 | 0.44 ± 0.11 |
wt-tumor | 1.02 ± 0.18 | 0.35 ± 0.13 | 0.17 ± 0.04 | 1.40 ± 0.39 | 0.28 ± 0.07 | 0.05 ± 0.01 |