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. 2023 Jun 1;50(10):3050–3061. doi: 10.1007/s00259-023-06272-7

Table 1.

[177Lu]Lu-FAPI-46 biodistribution results in HT-1080 and HEK-293 xenografts expressed as mean of the % injected activity per gram of tissue (%I.A./g) ± standard deviation (SD) (n = 4–5/group)

Organ HT-1080 xenografts HEK-293 xenografts
4 h 24 h 72 h 4 h 24 h 72 h
Blood 0.43 ± 0.04 0.03 ± 0.01 0.00 ± 0.00 0.65 ± 0.08 0.03 ± 0.01 0.00 ± 0.00
Lung 0.29 ± 0.03 0.05 ± 0.02 0.03 ± 0.00 0.41 ± 0.08 0.04 ± 0.01 0.01 ± 0.00
Liver 0.29 ± 0.02 0.21 ± 0.06 0.24 ± 0.05 0.35 ± 0.05 0.19 ± 0.07 0.10 ± 0.04
Kidney 1.19 ± 0.34 0.59 ± 0.05 0.39 ± 0.12 1.33 ± 0.19 0.38 ± 0.06 0.15 ± 0.10
Muscle 0.58 ± 0.38 0.09 ± 0.05 0.04 ± 0.03 0.49 ± 0.15 0.08 ± 0.03 0.01 ± 0.00
Femur 2.52 ± 0.38 0.61 ± 0.14 0.73 ± 0.08 2.22 ± 0.58 0.55 ± 0.22 0.19 ± 0.06
hFAP-tumor 9.63 ± 1.79 2.68 ± 0.74 1.58 ± 0.37 10.34 ± 4.55 3.39 ± 1.65 0.44 ± 0.11
wt-tumor 1.02 ± 0.18 0.35 ± 0.13 0.17 ± 0.04 1.40 ± 0.39 0.28 ± 0.07 0.05 ± 0.01