Table 2.
[177Lu]Lu-FAPI-46-F1D biodistribution results HT-1080 and HEK-293 xenografts expressed as mean of the % injected activity per gram of tissue (%I.A./g) ± standard deviation (SD) (n = 4–6/group)
| Organ | HT-1080 | HEK-293 | ||||
|---|---|---|---|---|---|---|
| 4 h | 24 h | 72 h | 4 h | 24 h | 72 h | |
| Blood | 1.21 ± 0.22 | 0.60 ± 0.05 | 0.04 ± 0.01 | 1.51 ± 0.28 | 0.59 ± 0.08 | 0.05 ± 0.01 |
| Lung | 0.87 ± 0.21 | 0.53 ± 0.01 | 0.18 ± 0.03 | 0.93 ± 0.13 | 0.55 ± 0.07 | 0.25 ± 0.04 |
| Liver | 0.67 ± 0.16 | 1.37 ± 0.04 | 1.23 ± 0.27 | 0.83 ± 0.25 | 1.35 ± 0.15 | 1.66 ± 0.31 |
| Kidney | 1.25 ± 0.08 | 1.02 ± 0.16 | 0.87 ± 0.20 | 1.28 ± 0.19 | 0.94 ± 0.06 | 0.73 ± 0.06 |
| Muscle | 1.35 ± 0.43 | 0.88 ± 0.10 | 0.41 ± 0.21 | 1.05 ± 0.27 | 0.80 ± 0.11 | 0.41 ± 0.06 |
| Femur | 4.91 ± 0.75 | 2.89 ± 0.08 | 2.02 ± 0.32 | 5.19 ± 0.86 | 3.04 ± 0.27 | 2.09 ± 0.23 |
| hFAP-tumor | 10.47 ± 2.47 | 6.42 ± 0.89 | 3.57 ± 0.73 | 17.16 ± 4.63 | 5.89 ± 1.29 | 1.43 ± 0.20 |
| wt-tumor | 2.26 ± 0.32 | 2.57 ± 0.42 | 1.14 ± 0.38 | 3.27 ± 1.89 | 1.99 ± 0.26 | 1.41 ± 0.38 |