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. 2023 Jun 1;50(10):3050–3061. doi: 10.1007/s00259-023-06272-7

Table 2.

[177Lu]Lu-FAPI-46-F1D biodistribution results HT-1080 and HEK-293 xenografts expressed as mean of the % injected activity per gram of tissue (%I.A./g) ± standard deviation (SD) (n = 4–6/group)

Organ HT-1080 HEK-293
4 h 24 h 72 h 4 h 24 h 72 h
Blood 1.21 ± 0.22 0.60 ± 0.05 0.04 ± 0.01 1.51 ± 0.28 0.59 ± 0.08 0.05 ± 0.01
Lung 0.87 ± 0.21 0.53 ± 0.01 0.18 ± 0.03 0.93 ± 0.13 0.55 ± 0.07 0.25 ± 0.04
Liver 0.67 ± 0.16 1.37 ± 0.04 1.23 ± 0.27 0.83 ± 0.25 1.35 ± 0.15 1.66 ± 0.31
Kidney 1.25 ± 0.08 1.02 ± 0.16 0.87 ± 0.20 1.28 ± 0.19 0.94 ± 0.06 0.73 ± 0.06
Muscle 1.35 ± 0.43 0.88 ± 0.10 0.41 ± 0.21 1.05 ± 0.27 0.80 ± 0.11 0.41 ± 0.06
Femur 4.91 ± 0.75 2.89 ± 0.08 2.02 ± 0.32 5.19 ± 0.86 3.04 ± 0.27 2.09 ± 0.23
hFAP-tumor 10.47 ± 2.47 6.42 ± 0.89 3.57 ± 0.73 17.16 ± 4.63 5.89 ± 1.29 1.43 ± 0.20
wt-tumor 2.26 ± 0.32 2.57 ± 0.42 1.14 ± 0.38 3.27 ± 1.89 1.99 ± 0.26 1.41 ± 0.38