Table 3.
[177Lu]Lu-FAPI-46-Ibu biodistribution results HT-1080 and HEK-293 xenografts expressed as mean of the % injected activity per gram of tissue (%I.A./g) ± standard deviation (SD) (n = 4/group)
| Organ | HT-1080 | HEK-293 | ||||
|---|---|---|---|---|---|---|
| 4 h | 24 h | 72 h | 4 h | 24 h | 72 h | |
| Blood | 1.07 ± 0.10 | 0.14 ± 0.03 | 0.01 ± 0.00 | 1.00 ± 0.18 | 0.10 ± 0.01 | 0.00 ± 0.00 |
| Lung | 0.83 ± 0.07 | 0.21 ± 0.03 | 0.07 ± 0.02 | 1.88 ± 2.29 | 0.15 ± 0.01 | 0.04 ± 0.01 |
| Liver | 0.96 ± 0.08 | 1.02 ± 0.70 | 0.50 ± 0.02 | 0.75 ± 0.11 | 0.58 ± 0.35 | 0.35 ± 0.04 |
| Kidney | 1.80 ± 0.15 | 1.15 ± 0.19 | 0.54 ± 0.11 | 1.33 ± 0.17 | 0.81 ± 0.11 | 0.25 ± 0.03 |
| Muscle | 0.97 ± 0.25 | 0.43 ± 0.28 | 0.12 ± 0.07 | 0.87 ± 0.36 | 0.28 ± 0.08 | 0.07 ± 0.03 |
| Femur | 3.62 ± 0.04 | 1.12 ± 0.12 | 0.51 ± 0.09 | 2.46 ± 0.88 | 0.81 ± 0.11 | 0.33 ± 0.08 |
| hFAP-tumor | 8.40 ± 1.97 | 5.09 ± 0.64 | 1.55 ± 0.58 | 5.03 ± 2.84 | 3.14 ± 0.49 | 0.88 ± 0.40 |
| wt-tumor | 1.96 ± 0.36 | 1.00 ± 0.25 | 0.28 ± 0.05 | 1.86 ± 1.25 | 0.52 ± 0.11 | 0.18 ± 0.05 |