Table 4.
[177Lu]Lu-FAPI-46-EB biodistribution results HT-1080 and HEK-293 xenografts expressed as mean of the % injected activity per gram of tissue (%I.A./g) ± standard deviation (SD) (n = 4/group)
| Organ | HT-1080 | HEK-293 | ||||
|---|---|---|---|---|---|---|
| 4 h | 24 h | 72 h | 4 h | 24 h | 72 h | |
| Blood | 11.59 ± 0.46 | 5.47 ± 0.85 | 1.63 ± 0.19 | 13.16 ± 2.19 | 6.85 ± 0.61 | 1.18 ± 0.05 |
| Lung | 5.45 ± 0.23 | 3.27 ± 0.60 | 1.64 ± 0.08 | 6.45 ± 1.19 | 3.98 ± 0.44 | 1.45 ± 0.06 |
| Liver | 2.80 ± 0.26 | 2.66 ± 0.31 | 2.78 ± 0.48 | 3.06 ± 0.36 | 3.05 ± 0.12 | 2.29 ± 0.23 |
| Kidney | 4.33 ± 0.12 | 5.02 ± 0.59 | 5.97 ± 0.49 | 4.70 ± 1.03 | 6.67 ± 0.67 | 4.86 ± 0.72 |
| Muscle | 1.31 ± 0.07 | 1.17 ± 0.13 | 0.85 ± 0.19 | 1.61 ± 0.17 | 1.39 ± 0.27 | 0.59 ± 0.25 |
| Femur | 2.35 ± 0.24 | 2.09 ± 0.21 | 1.34 ± 0.13 | 2.43 ± 0.26 | 2.51 ± 0.30 | 1.08 ± 0.24 |
| hFAP-tumor | 5.02 ± 0.29 | 5.44 ± 1.03 | 4.16 ± 0.19 | 12.58 ± 2.83 | 16.69 ± 1.01 | 6.75 ± 1.06 |
| wt-tumor | 3.70 ± 0.72 | 3.56 ± 0.76 | 3.75 ± 1.02 | 3.75 ± 0.40 | 4.25 ± 0.47 | 2.10 ± 0.07 |