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. 2023 Jun 1;50(10):3050–3061. doi: 10.1007/s00259-023-06272-7

Table 5.

[177Lu]Lu-FAP-2286 biodistribution results HT-1080 and HEK-293 xenografts expressed as mean of the % injected activity per gram of tissue (%I.A./g) ± standard deviation (SD) (n = 4/group)

Organ HT-1080 HEK-293
4 h 24 h 72 h 4 h 24 h 72 h
Blood 0.03 ± 0.01 0.00 ± 0.00 0.00 ± 0.00 0.04 ± 0.01 0.00 ± 0.00 0.00 ± 0.00
Lung 0.08 ± 0.01 0.03 ± 0.01 0.01 ± 0.00 0.07 ± 0.00 0.02 ± 0.00 0.01 ± 0.00
Liver 0.11 ± 0.02 0.08 ± 0.01 0.05 ± 0.01 0.11 ± 0.01 0.09 ± 0.00 0.03 ± 0.01
Kidney 5.15 ± 0.65 3.62 ± 0.51 1.58 ± 0.51 3.98 ± 0.42 2.33 ± 0.48 0.72 ± 0.22
Muscle 0.04 ± 0.01 0.02 ± 0.01 0.01 ± 0.00 0.06 ± 0.03 0.02 ± 0.01 0.01 ± 0.01
Femur 0.15 ± 0.05 0.10 ± 0.01 0.16 ± 0.06 0.27 ± 0.04 0.20 ± 0.01 0.04 ± 0.02
hFAP-tumor 3.42 ± 1.06 1.67 ± 0.50 0.64 ± 0.22 22.99 ± 3.13 13.49 ± 1.95 4.05 ± 0.99
wt-tumor 0.10 ± 0.01 0.08 ± 0.01 0.04 ± 0.01 0.28 ± 0.13 0.13 ± 0.05 0.02 ± 0.02