Table 6.
Radiation dosimetry estimation in tumors and critical organs expressed as mean absorbed dose (mGy/MBq). Results were obtained with OLINDA/EXM 1.0 by integrating the fitted time-activity curves
| Organ | [177Lu]Lu-FAPI-46 | [177Lu]Lu-FAPI-46-F1D | [177Lu]Lu-FAPI-46-Ibu | [177Lu]Lu-FAPI-46-EB | [177Lu]Lu-FAP-2286 |
|---|---|---|---|---|---|
| Kidneys | 4.69E-02 | 1.11E-01 | 6.75E-02 | 3.71E+00 | 2.04E-01 |
| Liver | 3.58E-02 | 1.18E-01 | 4.25E-02 | 3.23E-01 | 4.21E-03 |
| Red marrow | 4.05E-04 | 2.53E-03 | 6.50E-03 | 2.79E-02 | 1.78E-04 |
| HT-1080.hFAP tumor | 1.73E+00 | 3.67E+00 | 3.64E+00 | 7.25E+00 | 8.62E-01 |
| HEK-293.hFAP tumor | 1.72E+00 | 2.31E+00 | 1.75E+00 | 1.13E+01 | 6.76E+00 |