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. 2023 Jul 28;9:78. doi: 10.1038/s41421-023-00581-9

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — a Cryo-EM map of BANAL-20-52 (PDB ID: 8HXJ) and BANAL-20-236 (PDB ID: 8I3W) S trimer. Three protomers of BANAL-20-236 were colored in yellow, cyan, and magenta, and three protomers of BANAL-20-52 were colored in blue, orange, and pink. Left, side view; right, top view. b The monomeric structures of BANAL-20-236 (magenta) (PDB ID: 8I3W) and BANAL-20-52 (blue) (PDB ID: 8HXJ) S proteins are superimposed to those of SARS-CoV-2 WH strain (PDB ID: 7XU6) (yellow) and Omicron BA.2.75 (PDB ID: 7YQW) (gray). The superimposed individual domain structures and the indicated loops (RBD (top left), NTD (top right), S2 (bottom left) and SD1 and SD2 (bottom right)) are also shown. Both SARS-CoV-2 and omicron BA.2.75 S proteins here are in “down” conformations at an acidic pH. c Top view: Comparison of inter-RBD contacts of the BANAL-20-236 (red), BANAL-20-52 (blue) and Omicron BA.2.75 (gray) S-trimers. d Structural comparison of the angle formed by NTD-SD2-RBD of BANAL-20-236/52 and Omicron BA.2.75. Red, BANAL-20-236; blue, BANAL-20-52; gray, omicron BA.2.75.