Table 3.

Multivariable Cox regression analysis of IL-1B and IL-8 polymorphisms disease-free and overall survival in iCCA.

	Disease-free survival (DFS)		Overall survival (OS)
	Hazard ratio (95% CI)§	p	Hazard ratio (95% CI)#	p
IL-1B +3954 C > T (rs1143634)		.526		.013
C/T or T/T (favorable)	1		1
C/C (unfavorable)	1.233 (.645–2.360)		2.444 (1.204–4.962)
IL-8 -251 T > A (rs4073)		n.a.&		.026
T/T (favorable)	n.a.&		1
T/A (unfavorable)	n.a.&		2.318 (1.158–4.640)
A/A (unfavorable)	n.a.&		1.967 (.363–2.577)
Combined		n.a.&
0 unfavorable	n.a.&		1	.007
1 unfavorable	n.a.&		0.880 (0.268–2.895)
2 unfavorable	n.a.&		2.395 (0.747–7.895)

Based on Cox proportional hazards model, for DFS including: blood transfusions, microvascular invasion, lymphovascular invasion, lymph node positivity, UICC stage. For OS including: alkaline phosphatase, hemoglobin, C-reactive protein, blood transfusions, microvascular invasion, lymphovascular invasion, lymph node positivity, UICC stage, comprehensive complication index and hospitalization. Also see Supplementary Table 2 and 3.

CI confidence interval, iCCA intrahepatic cholangiocarcinoma, IL interleukin.

^§83 patients with complete data were included in the model.

^#84 patients with complete data were included in the model.

^&Not significant in univariable analysis (log-rank test), therefore variable was not included in multivariable analysis.

Significant values are in bold.