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. 2023 Jul 28;14:4551. doi: 10.1038/s41467-023-40272-3

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — The nAb titers against the Ancestral, Gamma, Delta and Omicron BA.1 and Omicron BA.5 variants of SARS-CoV-2 in plasma samples of individuals boosted with ARVAC CG 25 µg (N = 60 individuals) (a) or 50 µg (N = 20 individuals) (b) prior to the vaccine administration (d1) or after 14 days of booster administration (d14). Each point represents the nAb titer of a volunteer at the indicated time point and against the depicted viral variant. The nAb geometric mean titers (GMTs) and 95% CIs are shown as horizontal and error bars, respectively. The numbers depicted above the individual points for each specified time point and viral variant represent de GMT. The fold increase in the GMT from day 1 to day 14 (GMFR) for each specified variant are shown with a number followed by a ×. The dashed line represents the positivity threshold on the virus neutralization assay. Statistical differences were analyzed using the two-tailed Wilcoxon pair-matched test. P-values are depicted above the data sets that were compared. In panel (a) all P values were smaller than 10e-15; in panel (b) P = 0.000004 for Ancestral strain, Gamma and Omicron BA.1 VOCs, P = 0.000099 for Delta VOC and P = 0.000015 for Omicron BA.5.