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. 2023 Jul 28;13:12241. doi: 10.1038/s41598-023-39491-x

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Vertical transmission of intestinal microbiota altered by 5-aminosalicylic acid leads to a protective effect protect against dextran sulfate sodium-induced colitis. The severity of colitis was assessed on day 7 after dextran sulfate sodium (DSS)-induced colitis was initiated in the 5-aminosalicylic acid (5-ASA)-derived group and non-treated (NT)-derived group. Male data are shown (n = 5 in the NT-derived group and n = 11 in the 5-ASA-derived group) (A) disease activity index. (B) The length of the cecum, length of the colon, and the colon weight per length with representative macroscopic images. (C) Histological score of the colon with representative microscopic images (×200 and ×400). (D) Histological scores of score 1 (inflammatory cell infiltrate) and score 2 (intestinal architecture). (E) Body weight changes during DSS treatment. The data are the mean ± SEM. **p < 0.01, ***p < 0.001, Mann–Whitney U-test. Female data are shown in Supplemental Figure S9.