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. 2023 Dec 16;72(8):1144–1153. doi: 10.2337/db22-0639

Figure 4.

Figure 4

RH blunts the increase in R of PFH orexin GI neurons in response to low glucose concentration. Representative voltage responses to constant hyperpolarizing current pulses from AdGI (A) or sGI (B) neurons from RS- and RH-treated mice. The voltage response is directly proportional to the change in R. Both AdGI and sGI neurons from RS-treated mice increased the magnitude of the voltage response in 0.1 vs. 2.5 mmol/L glucose, whereas those from RH-treated mice did not. C: The percent change (%Δ) in R of sGI (open circles) and AdGI (closed circles) from RS- and RH-treated mice as glucose concentration decreased from 2.5 to 0.1 mmol/L. RH significantly decreased the percent change in R for sGI and adGI neurons, whether analyzed separately (sGI, P = 0.004, n = 3 RS and n = 4 RH; AdGI, P = 0.0003, n = 6 RS and n = 7 RH) or in combination (***P < 0.0001; C). There were no significant differences in the percent change in MP. Data analyzed by Student unpaired t test; individual values shown with mean and SD.