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. 2023 Dec 16;72(8):1144–1153. doi: 10.2337/db22-0639

Figure 6.

Figure 6

Modafinil prevents the change in glucose sensitivity of PFH GI neurons after RH. Representative voltage responses to constant hyperpolarizing current pulses from AdGI (A) or sGI (B) neurons from RS and RH mice treated with modafinil (150 mg/kg) 1 h prior to sacrifice. The voltage response is directly proportional to the change in R. C: The percent change (%Δ) in R and MP of sGI (open circles) and AdGI (closed circles) from RS and RH treated mice as glucose decreased from 2.5 to 0.1 mmol/L. There were no significant differences between sGI or AdGI neurons from RS- and RH-modafinil treated mice. This finding was independent of whether sGI and adGI neurons were analyzed separately or in combination (P > 0.05, Students unpaired t test, individual values shown with mean and SD).