Table 2.
Results From Seed-Based Correlation Analysis Demonstrating Significant Sex-Specific Associations Between Dentine Mn at Three Time Points and Intrinsic Functional Connectivity in Adolescents
| Exposure Time Point | Seed-to-Region Connectivity | Cluster (x, y, z) | Cluster Size | β | p-FDR |
|---|---|---|---|---|---|
| Prenatal | Left caudate—left occipital pole | (−04, −90, +08) | 223 | 0.67 | <.001 |
| Left putamen—left middle frontal gyrus | (−30, +26, +42) | 64 | −0.71 | .014 | |
| Left putamen—left occipital fusiform gyrus | (−28, −78, −16) | 60 | 0.67 | .014 | |
| Middle frontal gyrus—right occipital pole | (+14, −98, +12) | 99 | −0.92 | .003 | |
| Postnatal | Right putamen—right cerebellum | (+42, −68, −54) | 74 | −0.70 | .009 |
| Early Childhood | Left putamen—lateral occipital cortex, right superior division | (+12, −52, +58) | 90 | 0.64 | .003 |
| Middle frontal gyrus—middle temporal gyrus, left posterior division | (−50, −22, −04) | 138 | 0.74 | .002 |
All models controlled for age (years) and SES. Voxel threshold p < .001 (uncorrected); cluster threshold p < .05 (p-FDR corrected). Coordinates presented are in MNI space. All coefficients refer to sex-Mn interaction term.
FDR, false discovery rate; Mn, manganese; MNI, Montreal Neurological Institute; SES, socioeconomic status.