Table 3. Base-case and one-way sensitivity analysis results.
| Base-case | |||||
|---|---|---|---|---|---|
| Strategy | Cost (€) | Incremental cost (€) | Effect (QALY) | Incremental effect (QALY) | ICER (€/QALY) |
| SC | €749.71 | -0.018978463 | |||
| PACT | €175.48 | -€574.23 | -0.003262228 | 0.015716235 | -36, 537.24; Dominant |
| One-way sensitivity | |||||
| Parameter | Mean/point estimate (range) | Lower ICER value (€) | Upper ICER value (€) | ||
| Probability of discharge medication error | Point estimate (+/-20%) | ||||
| Standard care | 0.653 (0.5224-0.7836) | -36217.1131; Dominant | -36732.82; Dominant | ||
| Intervention | 0.139 (0.1112-0.1668) | -36165.69; Dominant | -36940.98; Dominant | ||
| Discharge medication error cost (€) | Mean (95%CI) | ||||
| Standard care | 1091.12 (702.51-1551) | -20390.73; Dominant | -55644.98; Dominant | ||
| Intervention | 638.73 (248.41-1074.17) | -39989.37; Dominant | -32686.06; Dominant | ||
| Pharmacist cost (€) | Mean (95%CI) | ||||
| Standard care | 37.21 (29.18-47.39) | -36026.31; Dominant | -37184.98; Dominant | ||
| Intervention | 86.70 (58.84-119.77) | -38309.93; Dominant | -34433.05; Dominant | ||
| Utility decrement | Mean (+/-20%) | ||||
| Standard care | -0.02906349626 (-0.0232508,-0.034876196) | -48171.29; Dominant | -29429.58; Dominant | ||
| Intervention | -0.023469269 (-0.01877542, -0.028163123) | -35080.89; Dominant | -38119.75; Dominant | ||
| Distributions and hyperparameters used in the PSA | |||||
| Parameter | Distribution | ||||
| Probabilities | |||||
| Discharge medication error, standard care | Beta (372.96, 198.19) * † | ||||
| Discharge medication error, PACT | Beta (44.78, 277.36) * † | ||||
| Costs | |||||
| Cost of discharge medication error SC | Gamma (24393.59, 0.04473) * | ||||
| Cost of discharge medication error PACT | Gamma (9636.58, 0.06628) * | ||||
| Cost of pharmacist SC | Gamma (59903.58, 0.00062) * | ||||
| Cost of pharmacist PACT | Gamma (30197.42, 0.00287) * | ||||
| Utilities | |||||
| Decrement SC | 1-(Gamma) (13279.82, 0.00008) * | ||||
| Decrement PACT | 1-(Gamma) (2828.56, 0.00036) * | ||||
*Alpha and beta hyperparameters of the beta and gamma distributions in parentheses
†SD fixed at 0.2 during estimation of SE