Table 3. Detailed laboratory investigation schedule.

Day from recruitment	D0	D1	D3	D7	D28
Blood culture	3 ml			3 ml (cases)
PK studies (cases only)	2 x 0.25 ml			1 x 0.25 ml
Whole blood (Endotoxin)	1.5 ml		1.5 ml	1.5 ml
Whole blood EDTA (genetics)	1 ml
Whole blood (transcriptomics, CRP, procalcitonin, calprotectin, gut barrier function)	4.5 ml		2 ml	2 ml	4.5 ml
Total blood volume research	10.4 ml	0.5 ml	3.5 ml	7 ml	5 ml
Urine	x	x	x

PK, pharmacokinetics; CRP, C-reactive protein.