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Pathway-specific mutants of IRF3 and their functions. Mouse IRF3 (IRF3-Wt) with its critical amino acids and pathway-specific mutants (IRF3-S1 and IRF3-M1) are shown. Wt IRF3 is capable of transcriptional, RIPA, and RIKA functions, IRF3-S1 is active in RIPA and RIKA but inactive in transcriptional activity, and IRF3-M1 is active only in RIKA but inactive in transcriptional and RIPA activities.
