Figure 6.

Low- (a) and high-dose (b) PTU- associated changes on the plasma metabolome after short-term (2 weeks), long-term drug administration (4 weeks), and following a 2-week recovery phase after long-term exposure. Differences in global metabolome profiles comparing treatment (colored) to control (grey) analyzed by PCA with significance determined by PERMANOVA. Differences in metabolite concentrations visualized in volcano plot depicting log2 fold changes of treatment versus control with significance calculated by the Mann-Whitney U test and p-values corrected for multiple testing using the Benjamini-Hochberg method.