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Construction of pWHcIm and pWHsIm. Both pWHcIm and pWHsIm were constructed on the basis of pcDNA3 (Invitrogen). The fragments from the WHV genome comprising the complete reading frame of WHcAg and WHsAg (including pre-S2) were cloned into pcDNA3 as described in Materials and Methods. The expression of WHcAg and WHsAg is under the control of the CMV promoter of the vector. The cloned fragments of the WHV genome are numbered according to Girones et al. (21).
