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Anti-WHcAg response in pWHcIm-immunized mice. Mice were immunized thrice with 100 μg of plasmid pWHcIm (▴) or control (■) at 3-week intervals. Vaccinations with plasmid are indicated by ▾. Anti-WHcAgs were tested with sera from mice collected at weeks 0, 3, and 12. The mean titer of anti-WHcAg is shown.
