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. 2023 Jul 7;16(7):977. doi: 10.3390/ph16070977

Figure 11.

Figure 11

Illustrative kidney tissue congestion microscopic presentation (HE staining; magnification 200×; scale bar 200 μm) in the sotalol, control rats (small letters) and BPC 157-treated rats (capitals), assessed at 15 min (a,B), 90 min (c,D) and 180 min (e,F,g,H) following application of sotalol. Medication was given as an early application at 5 min after sotalol (a,B,c,D,e,F), or as delayed post-treatment (at 90 min and assessment at 180 min sotalol-time) (g,H), saline (a,c,e,g) or BPC 157 therapy (B,D,F,H) given intragastrically. Sotalol-rats treated with saline consistently had a marked dilatation of the terminal cortical blood vessels and glomerular capillary loop (a,c,e,g). Sotalol-rats treated with BPC 157 consistently exhibited either no dilatation (B,D,H) (period relative to therapy application 0–15 min, 0–90 min, 90–180 min sotalol-time) or discrete dilatation of cortical vessels (F) (period relative to therapy application, 0–180 min sotalol-time).